Molecular imaging in Parkinson's Disease
Cristina Polito.
Elektronisk ressurs Italiensk 2011
| Omfang | 1 online resource (68 pages) : : illustrations; digital, PDF file(s).
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| Opplysninger | The present work explores brain functional changes in drug-naïve Parkinson's disease (PD) patients by means of molecular imaging techniques. Thirty-one consecutive drug-naïve PD patients from the Neurological Clinic of the University of Florence underwent clinical assessment, neuropsychological assessment, MRI, [123I]FP-CIT SPECT, [18F]FDG PET. First, [18F]FDG-PET was employed to identify in drug-naïve PD patients brain metabolic alteration uniquely related to disease process and not modulated by anti-parkinsonian therapeutic intervention. Second, [18F]FDG-PET and [123I]FP-CIT SPECT were employed together to explore the early functional changes in brain function related to dopaminergic depletion in the putamen and in the caudate nucleus.
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| Emner | |
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| ISBN | 9788866550419
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