Essentials of Organic Chemistry : For Students of Pharmacy, Medicinal Chemistry and Biological Chemistry
Paul M. Dewick
Bok Engelsk 2013 · Electronic books.
| Annen tittel | |
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| Utgitt | Hoboken : : Wiley, , 2013.
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| Omfang | 1 online resource (712 p.)
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| Opplysninger | Description based upon print version of record.. - Title Page; Contents; Preface; 1 Molecular representations and nomenclature; 1.1 Molecular representations; 1.2 Partial structures; 1.3 Functional groups; 1.4 Systematic nomenclature; 1.5 Common groups and abbreviations; 1.6 Common, non-systematic names; 1.7 Trivial names for complex structures; 1.8 Acronyms; 1.9 Pronunciation; 2 Atomic structure and bonding; 2.1 Atomic structure; 2.2 Bonding and valency; 2.3 Atomic orbitals; 2.4 Electronic configurations; 2.5 Ionic bonding; 2.6 Covalent bonding; 2.6.1 Molecular orbitals: σ and π bonds; 2.6.2 Hybrid orbitals in carbon. - 2.6.3 Hybrid orbitals in oxygen and nitrogen2.7 Bond polarity; 2.8 Conjugation; 2.9 Aromaticity; 2.9.1 Benzene; 2.9.2 Cyclooctatetraene; 2.9.3 Hückel's rule; 2.9.4 Kekulé structures; 2.9.5 Aromaticity and ring currents; 2.9.6 Aromatic heterocycles; 2.9.7 Fused rings; 2.10 Resonance structures and curly arrows; 2.11 Hydrogen bonding; 2.12 Molecular models; 3 Stereochemistry; 3.1 Hybridization and bond angles; 3.2 Stereoisomers; 3.3 Conformational isomers; 3.3.1 Conformations of acyclic compounds; 3.3.2 Conformations of cyclic compounds; 3.4 Configurational isomers. - 3.4.1 Optical isomers: chirality and optical activity3.4.2 Cahn-Ingold-Prelog system to describe configuration at chiral centres; 3.4.3 Geometric isomers; 3.4.4 Configurational isomers with several chiral centres; 3.4.5 Meso compounds; 3.4.6 Chirality without chiral centres; 3.4.7 Prochirality; 3.4.8 Separation of enantiomers: resolution; 3.4.9 Fischer projections; 3.4.10 D and L configurations; 3.5 Polycyclic systems; 3.5.1 Spiro systems; 3.5.2 Fused ring systems; Box 3.18; 3.5.3 Bridged ring systems; 4 Acids and bases; 4.1 Acid-base equilibria; 4.2 Acidity and pKa values. - 4.11.2 Isotopic labelling using basic reagents4.11.3 Amphoteric compounds: amino acids; 4.11.4 pKa and drug absorption; 5 Reaction mechanisms; 5.1 Ionic reactions; 5.1.1 Bond polarity; 5.1.2 Nucleophiles, electrophiles, and leaving groups; 5.2 Radical reactions; 5.3 Reaction kinetics and mechanism; 5.4 Intermediates and transition states; 5.5 Types of reaction; 5.6 Arrows; 6 Nucleophilic reactions: nucleophilic substitution; 6.1 The SN2 reaction: bimolecular nucleophilic substitution; 6.1.1 The effect of substituents; 6.1.2 Nucleophiles: nucleophilicity and basicity; 6.1.3 Solvent effects. - 4.3 Electronic and structural features that influence acidity4.3.1 Electronegativity; 4.3.2 Bond energies; 4.3.3 Inductive effects; 4.3.4 Hybridization effects; 4.3.5 Resonance/delocalization effects; 4.4 Basicity; 4.5 Electronic and structural features that influence basicity; 4.5.1 Electronegativity; 4.5.2 Inductive effects; 4.5.3 Hybridization effects; 4.5.4 Resonance/delocalization effects; 4.6 Basicity of nitrogen heterocycles; 4.7 Polyfunctional acids and bases; 4.8 pH; 4.9 The Henderson-Hasselbalch equation; 4.10 Buffers; 4.11 Using pKa values; 4.11.1 Predicting acid-base interactions. - 6.1.4 Leaving groups. - Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples.In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding a
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| ISBN | 0470016655. - 0470016663. - 9780470016657. - 9780470016664
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