No association between familial Alzheimer disease and cytochrome P450polymorphisms
H. Yamada
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 204- 207
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| Opplysninger | Four different loci have been found to be involved in the developmentof familial Alzheimer disease (AD). The epsilon 4 allele of theapolipoprotein E gene on chromosome 19 is a susceptibility factor forAD, and in a small number of AD families, dominant mutations withhigh penetrance are operating in genes on chromosomes 1, 14 and 21.However, the disease in many familial AD cases cannot be explained bythese genes; thus, other genetic factors involved in the etiology ofAD should exist. Recently, an association between the cytochrome P4502D6B (CYP2D6B) allele and the Lewy body variant of AD was reported.In the present study, 54 unrelated Swedish familial AD patients and56 age- and sex-matched healthy controls were studied with respect tothe two genetic polymorphisms of oxidative drug metabolism, CYP2D6and CYP2C19. No significant association was found between the defectCYP2D6A and -B or CYP2C19m1 and -m2 alleles and familial AD patients,with the exception of a lower frequency of CYP2D6B in the male ADcases.
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