Carnitine acyltransferases are not changed in Alzheimer disease
I. Maurer
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 71- 76
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| Opplysninger | We evaluated the activities of carnitine palmitoyltransferase (CPT),carnitine octanoyltranferase (COT), and carnitine acetyltransferase(CAT) in the frontal cortex, temporal cortex, parietal cortex,hippocampus, and cerebellum of Alzheimer disease (AD) patients andnormal human brains. There were no significant differences in totalCPT activity, its inhibition by malonyl-CoA, the effect of thedetergent Triton X-100 on CPT activity, COT activity, and CATactivity in any of the brain regions examined, whether activitieswere expressed as grams of wet weight or corrected for noncollagenprotein content. The addition of Triton X-100 increased CAT activityby 50%. Our results suggest that there is no defect of fatty acidtransport within the AD brain cell. Total CPT activity, COT activity,and CAT activity are not affected in AD nor is the ratio of CPT I toCPT II altered in the AD versus the normal human brain.
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| Emner |
