Typology of Alzheimer's disease: findings from CERAD data. 2(2).
G.G. Fillenbaum
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | 105- 127
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| Opplysninger | To identify heterogeneity in Alzheimer's disease (AD) we analyzedclinical and neuropsychological data obtained from the first 718 ADpatients submitted to the Consortium to Establish a Registry forAlzheimer's Disease (CERAD). These patients, who met stringentexclusion criteria, were entered by 23 tertiary US medical centersand had the advantages of uniform evaluation, substantial size andreduction in selection biases reflecting investigator interests. AGrade of Membership (GoM) analysis was used. GoM, based in fuzzy settheory, identifies the underlying pure types in the data. GoMrecognizes that individuals need not fall crisply into a particulartype, but that their characteristics may fit different pure types todifferent extents. Clinical and neuropsychological data obtained atentry were analyzed. Six clinical pure types were identified: AD withparkinsonism; AD with depressive symptomatology; AD with mildlanguage problems (parkinsonism and depressive symptoms absent); ADpresenting with impaired cognitive status and problems performinginstrumental activities of daily living; late onset, mild AD; lateonset AD of long duration, severe at entry and with additionalchronic disease present. Five neuropsychological pure types wereidentified. They differed primarily in level of performance of themeasures examined. No notable relationships between the clinical andneuropsychological pure types were found. Additional pure types maybe present (e.g. Familial AD), but cannot be identified in theabsence of information in the data base. It is clear, however, thatin a group of AD patients meeting strict criteria, heterogeneity ofdisease is present.
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| Emner |
