Neuropathological findings in patients with clinical diagnoses of probable Alzheimer's disease.
Bird TD
Bok Engelsk
| Utgitt | Psychiatry Service, American Lake VA Medical Cente
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| Omfang | 5 s.
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| Utgave | Kopi
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| Opplysninger | To assess prospectively the accuracy of standardantemortem clinical diagnostic criteria for Alzheimer's disease, post-mortemexaminations were performed on 25 patients who had met DSM-IIIcriteria for primary degenerative dementia and National Institute ofNeurological and Communicative Disorders and Stroke criteria for probableAlzheimer's disease. Seventeen patients (68%) met neuropathologicalcriteria for Alzheimer's disease. Two presenile-onset patients haddiffuse neocortical senile plaques of insufficient number for definiteAlzheimer's disease. Six patients had non-Alzheimer's disease diagnoses. Fiveof these six had presenile-onset dementia. These results suggest cautionin the antemortem diagnosis of Alzheimer's disease in presenile-onsetdementia.
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| Emner |
