Psychiatric features in diffuse Lewy body disease: A clinicopathologic study using Alzheimer's disease and Parkinson'sdisease comparison groups
L.A. Klatka
Bok Engelsk 1996
| Utgitt | 1996
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| Omfang | Side 1148- 1152
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| Opplysninger | We conducted a retrospective study to determine the frequency ofdepression, hallucinations, and delusions in patients with diffuseLewy body disease (DLBD) and to compare these findings with those inAlzheimer's disease (AD) and Parkinson's disease (PD). One hundredtwelve subjects were included in the study. Of these, 28 subjectswere diagnosed with DLBD, 58 with AD, and 26 with PD at autopsy. Mainoutcome measures included the percentages of subjects in each of thethree categories in whom depression, hallucinations, or delusionswere reported at any time during the course of the illness.Hallucinations and delusions were further classified by type. Wefound that depression was more common in DLBD (50.0%) than in AD(13.8%) (chi(2) = 13.00, p = 0.0003). There was no difference in thefrequency of depression in DLBD and PD (57.7%) (chi(2) = 0.32, p =0.57). Hallucinations were reported more frequently in DLBD (60.7%)than in AD (34.5%) (chi(2) = 5.30, p = 0.021). There was nodifference in the frequency of hallucinations in DLBD and PD (53.8%)(chi(2) = 0.26,p = 0.61). Delusions were more common in DLBD (57.1%)than in PD (15.4%) (chi(2) = 10.08, P = 0.0015). There was nodifference in the frequency of delusions in DLBD and AD (53.4%)(chi(2) = 0.10, p = 0.75). There was a male predominance of DLBDcases and PD cases; AD cases were predominantly women. We concludethat psychiatric features are very common in DLBD and should be acentral diagnostic criterion for the disease.
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