Human aging brain disorders: Role of antioxidant enzymes


R. de la Torre
Bok Engelsk 1996
Utgitt
1996
Omfang
Side 885- 888
Opplysninger
In order to investigate the role of two free radical detoxificantenzymes in patients with aging brain disorders, superoxide dismutase(SOD) and catalase (CAT) activities have been measured in blood frommale and female human patients of different ages with several typesof aging brain disorders. When compared with activities in the normalpopulation, we have detected: 1) SOD and CAT activities are decreasedin patients with Parkinson disease. 2) SOD activity seems to benormal and CAT activity is decreased in patients with dementia. 3) Inthe patients with stroke, SOD activity is normal, while CAT activityis decreased. SOD activity was measured in red blood cells using theMinami and Yoshikawa method. CAT activity was measured in hemolysatesby the method of Aebi. We can conclude that SOD and CAT activities inpatients with Parkinson disease are decreased.
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