Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia
Elizabeth H. et al. Aylward
Bok Engelsk
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| Opplysninger | CONCLUSIONS: In conjunction with findings from previous research, the authors conclude that HIV-dementia is associated whith specific gray matter volume reduction in basal ganglia and posterior cortex, as well as with generalized volume reduction of white matter.. - METHOD: THe authors measured volumes of CSF and gray and white tissue on cranial magnetic resonance images from homosexual men who were 1) infected with HIV with HIV-associated dementia complex, 2)infected with HIV without dementia, and 3) HIV seronegative.. - OBJECTIVE: The athors recently reported smaller basal ganglia volumes for patients with HIV-associated dementia than for HIV-infected patients without dementia and a seronegative comparison group. The purpose of the current study was to determine whether HIV dementia is associated with volume reductions in other brain regions.. - RESULTS: Results suggest that loss of white matter ccurs with HIV infection and is more severe in HIV-positive patients with dementia than in those without dementia. There was some generalized volume reduction in gray matter in HIV-positive demented patients, although group differnces did not reach significance when adjusted for age. Volume of posterior cortex, however, was significantly smaller among HIV-positive demented patients than in ether remaining group. There were no significant differences between HIV-positive nondemented patients and HIV-negative subjects in these regions.
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