Frontal-subcortical cicuits and human behavior
Jeffrey L. Cummings
Bok Engelsk
| Omfang | 8 s.
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| Utgave | Særtykk
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| Opplysninger | ABSTRACT: OBJECTIVE: -This synthetic review eas performed to demonstrate the utility of frontal-subcortical cicuits in the explanation of a wide range of human behavioral disorders.. - CONCLUSIONS-Frontal-subcortical cicuits mediata many aspects of human behavior.. - DATA EXTRACTION- Information was used if the report from which it was taken met study selection criteria.. - DATA SOURCES: -Reports of patients with degenerative disorders or focal lesions involving frontal lobe or linked subcortical structures were chosen from the English literature. Individual case reports and group investigations from peer-reviewed journals were evaluated. - DATA SYNTHESIS: - Five parallel segregated cicuits link the frontal lobe and subcortical sttructures. Clinical syndromes observed with frontallobe injury are recapitulated with lesions of subcortical member structures of the circuits. each prefrontal cicuit has a signature behavioral syndrome: executive function deficits occur with leions of the dorsolateral prefrontal cicuit, disinhibition with lesions of the orbitofrontal circuit, and apathy with injury to the anterior cingulate circuit. Depression, mania, and obsessive-compulsive disorder may also be mediated by frontal-subcortical cicuits. Movement disorders identify involvement of the basal ganglia component of frontal-subcortical cicuits-. - STUDY SELECTION: - Studies were included if they describe patient behavior in detail or reported pertinent neuropsychological findings and had compelling evidence of a disorder affecting frontal-subcortical cicuits.
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