A Pharmacology Primer : Theory, Application and Methods


Terry. Kenakin
Bok Engelsk 2009 · Electronic books.
Annen tittel
Utgitt
Burlington : : Elsevier Science, , 2009.
Omfang
1 online resource (410 p.)
Utgave
3rd ed.
Opplysninger
Description based upon print version of record.. - Front Cover; A Pharmacology Primer: Theory, Applications, and Methods; Copyright Page; Dedication Page; Contents; Preface; Preface to the Second Edition; Chapter 1 : What Is Pharmacology?; 1.1. About This Book; 1.2. What Is Pharmacology?; 1.4. Pharmacological Test Systems; 1.5. The Nature of Drug Receptors; 1.6. Pharmacological Intervention and the Therapeutic Landscape; 1.8. What Is Affinity?; 1.9. The Langmuir Adsorption Isotherm; 1.10. What Is Efficacy?; 1.11.1. Potency and Maximal Response; 1.11.2. p-Scales and the Representation of Potency; 1.12. Chapter Summary and Conclusions. - 11.5.12. Allosteric Insurmountable Antagonism: Operational Model with Variable SlopeChapter 12 : Statistics and Experimental Design; 12.3.4. Paired Data Sets; 12.4. How Consistent Is Experimental Data with Models?; 12.4.10. One or More Regression Lines? Analysis of Covariance; Chapter 13 : Selected Pharmacological Methods; Chapter 14 : Exercises in Pharmacodynamics and Pharmacokinetics; 14.3.8. Antagonist Potency Variably Dependent on Agonist Concentration; 14.5.1. Surrogate Screens; 14.6. Pharmacokinetics; 14.6.1. Clearance; 14.6.2. Drug-Drug Interactions; 14.6.3. Distribution I. - 14.6.4. Distribution II. - Chapter 4 : Pharmacological Assay Formats: Binding4.2.1. Saturation Binding; Chapter 5 : Agonists: The Measurement of Affinity and Efficacy in Functional Assays; 5.3. Recombinant Functional Systems; Chapter 6 : Orthosteric Drug Antagonism; 6.5. Agonist-Antagonist Hemi-Equilibria; 6.8.9. Derivation of the Method of Gaddum for Noncompetitive Antagonism; 6.8.10. Relationship of pA2 and pKB for Insurmountable Orthosteric Antagonism; 6.8.11. Resultant Analysis; Chapter 7 : Allosteric Drug Antagonism; 7.4.3. Variable Effects on Efficacy (epsiv 0); 7.8. Derivations; 14.2.9. Lack of Agonist Effect. - Chapter 8 : The Process of Drug Discovery8.3. Pharmacodynamics and High-Throughput Screening; 10.2.1. Target Validation and the Use of Chemical Tools; Chapter 9 : Pharmacokinetics; 9.4.3. General Pharmacokinetics; Chapter 10 : Target- and System-Based Strategies for Drug Discovery; Chapter 11 : ""Hit"" to Drug: Lead Optimization; 11.5.5. Relationship of pA2 and pKB for Insurmountable Allosteric Antagonism; 11.5.10. Allosteric Antagonism with Changes in Efficacy: Variable Slope; 11.5.11. Orthosteric Insurmountable Antagonism: Operational Model with Variable Slope. - ReferencesChapter 2 : How Different Tissues Process Drug Response; 2.7. The Measurement of Drug Activity; 2.10. Chapter Summary and Conclusions; 2.11. Derivations; 2.11.1. Series Hyperbolae Can Be Modeled by a Single Hyperbolic Function; 2.11.2. Successive Rectangular Hyperbolic Equations Necessarily Lead to Amplification; 2.11.3. Saturation of Any Step in a Stimulus Cascade by Two Agonists Leads to Identical Maximal Final Responses for the Two Agonists; Chapter 3 : Drug-Receptor Theory; 3.7. Two-State Theory; 3.14.8. Derivation of the Cubic Ternary Complex Model. - This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments.The ideal book for researchers in drug discovery
Emner
Sjanger
Dewey
ISBN
9780123745859

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