The Cambridge handbook of successful aging
edited by Rocío Fernández-Ballesteros, Athanase Benetos, Jean-Marie Robine.
Bok Engelsk 2019 · Electronic books.
| Medvirkende | Benetos, Athanase, (editor.)
Fernández Ballesteros, Rocío, (editor.) Robine, Jean-Marie, (editor.) |
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| Omfang | 1 online resource (xiv, 648 pages) : : digital, PDF file(s).
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| Utgave | 1st ed.
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| Opplysninger | Title from publisher's bibliographic system (viewed on 17 Jan 2019).. - Cover -- Half Title -- Title page -- Imprints page -- Contents -- List of Figures -- List of Tables -- List of Contributors -- Introduction: Some Traits about This Handbook of Successful Aging -- About This Handbook -- Part I: Biomedical Aspects -- Part II: Psychosocial Factors -- Part III: Socio-Demographic Issues -- References -- 1 The Concept of Successful Aging and Related Terms -- Antecedents -- The Meaning of Successful Aging -- Semantic Network of Successful Aging -- Most Frequent Outcomes and Predictors/Determinants Used in Cross-Sectional and Longitudinal Studies in the Field -- Conceptual Definitions of Successful Aging and Related Terms Proposed by Authors -- Common Problematic Issues -- Testing This Semantic Network -- Construction of the Meaning of Successful Aging and Related Terms -- Testing Hypotheses about the Semantic Network of Aging Well through SEM with Data from Two Different Studies -- Conclusions -- References -- 2 The Biomedical Bases of Successful Aging -- Is There a Genuine Potential for Preventing Functional Decline, Thereby Increasing the Probability of Successful Aging? -- To Go Further, Can Biomedical Progress Alter the Limits of Human Maximum Longevity and Stop the Aging Process? -- References -- 3 Successful Aging and the Longevity Revolution -- The Continuing Increase in Life Expectancy -- The Rectangularization of the Survival Curve -- The Revolution of Adult Longevity -- Are Centenarians a Model of Successful Aging? -- The Variability of End-of-Life Trajectories -- Trade-Off and Dynamic Approach -- References -- Part I Biomedical Aspects -- 4 The Connection between Cellular Senescence and Age-Related Diseases -- Introduction -- Why Do Somatic Cells Have to Senesce? -- How to Define Cell Senescence(s)? -- How Is Senescence Activated? -- What Are the Phenotypic Changes Induced by Senescence?.. - Basic Requirements of Macro-/Micronutrients in Older Adults -- Energy -- Protein -- Vitamins and Minerals -- Vitamin D -- Macro- and Micronutrients with Special Relevance for Muscle Strength and Muscle Function in Older Persons -- Protein and Specific Amino Acids -- Optimal Protein Intake -- Branched-Chain Amino Acids -- Potential Ceiling Effect of Protein Intake in Older Persons -- The Relevance of Protein for Frailty and Sarcopenia Treatment -- Lipids -- Vitamin D -- The Relevance of Body Composition for Muscle Function and Mobility in Older Persons -- References -- 14 Gerontechnologies and Successful Aging -- Introduction -- Successful Aging -- Gerontechnologies -- The Numeric Revolution -- The Birth of Gerontechnologies -- Domains of Application -- Typology -- Adoption and Acceptance -- Ethical Issues -- Perspectives and Danger -- Conclusions -- References -- 15 Optimization of Drug Use in Older People: A Key Factor for a Successful Aging -- Introduction -- Drug-Related Problems -- Inappropriate Prescribing -- Medication Non-Adherence -- Unintended Medication Discrepancies -- Goal of This Chapter -- What Needs to Be Optimized -- Inappropriate Prescribing -- Potentially Inappropriate Medication (PIM) -- Non-Adherence -- Determinants of Adherence to Pharmacotherapy -- Adherence and Older People, Why Are They Vulnerable? -- Medication Discrepancies at Transition Moments -- Types of Discrepancies -- Potential Clinical Impact -- Optimization of Drug Use -- Medication Reconciliation Definition, Process, Added Value -- Impact of MedRec -- Tools to Avoid Discrepancies -- Prescribing Optimization -- When to Review Medications? -- Impact of a Reliable Medication Review -- Tools for Detection of Potentially Inappropriate Prescribing (PIP) -- Explicit Tools -- Implicit Tools -- Judicious Drug Cessation or Deprescribing.. - Influence of Metabolic Factors, Diet, and Physical Activity on Arterial Stiffness -- Diabetes -- Obesity and Metabolic Factors -- Effects of Nutrients and Diet Patterns -- Role of Physical Activity -- Effects of Drug Treatment -- Conclusions and Perspectives -- References -- 10 Prevention of Frailty -- Introduction -- Global Aging -- Inadequacy of Traditional Healthcare Models -- Frailty -- Definition of Frailty -- Pathogenesis of Frailty -- Need for Interventions to Prevent Frailty -- Interventions to Prevent Frailty -- Healthy Aging -- To Ensure Access to Appropriate Health Services to Older Persons -- To Pursue Raising Awareness and Improve Health Education Programs -- Physical Exercise -- Nutritional Interventions -- Comprehensive Geriatric Assessment -- Development of New Models of Care -- Conclusion -- References -- 11 Preventive Effects of Physical Activity in Older People -- Functional Capacity and Mobility -- Frailty and Sarcopenia -- Bone Density and Osteoporosis -- Preventing Falls and Fractures -- Impaired Cognition and Memory Disorders -- Secondary Prevention and Rehabilitation of Clinical Cognitive Disorders -- Mental and Social Dimensions of Physical Activity -- How to Activate Older People to Exercise -- Conclusions -- References -- 12 Nutrition and Cognition -- Introduction -- Screening and Assessment of Nutritional Status -- Nutritional Status in Cognitive Decline -- Nutrients -- Antioxidants -- Vitamins -- Vitamin B -- Vitamin C -- Vitamin D -- Vitamin E -- Omega-3 Polyunsaturated Fatty Acids (Omega-3 PUFA) -- Polyphenols -- Flavonoids -- Carotenoids -- Caffeine -- Alcohol -- Diets -- Calorie Restriction -- Ketogenic Diets -- Multi-component Approach -- The Mediterranean Diet -- Medical Foods -- Conclusion -- References -- 13 Nutrition, Muscle Function, and Mobility in Older People.. - Other Tools to Support Prescribing Optimization.. - Study Designs for Identification of Gene-Lifestyle Interaction -- Known Genetic and Lifestyle Factors Associated with Human Longevity -- Genetic Factors Associated with Human Longevity -- Lifestyle Factors Associated with Human Longevity -- The Influence of the ApoE Gene on Life Span -- ApoE-Age Interaction -- ApoE-Lifestyle Interactions on Longevity -- Perspectives -- References -- 8 Plasticity of the Brain and Cognition in Older Adults -- What Is Brain Plasticity -- Synaptic Strengthening and Weakening -- Remodeling the Physical Brain by Plasticity -- Neurogenesis -- Example of Factor Modulating Plasticity: Sleep -- Aging Effect on Brain Plasticity -- The Brain Is Continuously Plastic -- Context- and Outcomes-Dependent Release of Neuromodulators in Older Brains -- Most Plasticity-Induced Changes Are Reversible -- Age-Related Impairment and Resilience against Neurodegenerative Disease Onset -- How to Improve and Enhance Brain Plasticity and Cognition? -- Mechanisms of Successful Cognitive Aging -- Maintenance -- Compensation -- Selection -- Novelty and Challenge: Environmental Stimulation -- Cognitive Training -- Exercise -- Sleep -- Pharmacologic Interventions -- Conclusion -- References -- 9 Arterial Stiffness and Blood Pressure during the Aging Process -- Introduction -- Impact of the Development of Arteriosclerosis on Cardiovascular Diseases and Other Age-Related Disease -- From Arterial Aging to the Decompensated Heart -- From Vascular Stiffening and Cognitive Decline -- BP and CV Risk during the Aging Process -- Do We Have to Reduce BP in Older Subjects? -- Noninvasive Methods to Measure Arteriosclerosis: Methodological Aspects and Clinical Interest -- Analysis of Pressure Waveforms and Augmentation Index (Aix) -- Pulse Pressure Amplification (PPA) -- Arterial Stiffness Measured by PWV.. - What Are the Relationships between Senescence and the Longevity Pathways? -- What Are the Relationships between Senescence and Age-Related Diseases? -- Osteoporosis -- Neurodegenerative Diseases -- Atherosclerosis -- Type 2 Diabetes -- Cataract -- Respiratory Diseases -- Cancer -- Conclusion - Perspectives -- References -- 5 From Inflamm-Aging to Immunosenescence -- Introduction -- What Is Inflamm-Aging and What Does It Mean? -- What Are the Consequences of This Basal Activation State? -- What Could Be the Molecular Mechanism of This Sustained Activation? -- How the Inflamm-Aging Is Participating to Immunosenescence? -- What Is Inflamm-Aging and Immunosenescence in Evolutionary Perspective? -- Geroscience, Age-Related Diseases, and Health Span? -- Conclusion -- References -- 6 Telomere Dynamics and Aging Related Diseases -- The Meaning of Aging -- Telomere Length and Its Link with Cellular Senescence -- Link between Telomere, Longevity, and Aging-Related Diseases -- Telomeres and Longevity: What We Have Learned from Animal Models and Clinical Studies -- The "Gender Effect" -- Genetic Diseases -- Telomere Length and Cancer -- Telomere Length and Degenerative Diseases -- The Biomarker Hypothesis -- Regulation of Telomere Length In Vivo: Respective Roles of LTL at Birth and Telomere Attrition During Body Growth and Adult ... -- Telomere Length at Birth -- Telomere Attrition in Early Life -- Telomere Attrition During Adult Life -- New Paradigm: Telomere as a Determinant in Aging Diseases -- The Cancer/Degenerative Disease Trade-Off -- Short Telomeres: A Bio-Determinant of Atherosclerotic Cardiovascular Disease -- Conclusions -- References -- 7 Gene-Lifestyle Interactions in Longevity -- Introduction -- The Importance of Studying Longevity and Gene-Environment Interactions -- Gene-Environment Interaction Assessment -- Measuring Interaction.. - Recent studies show that more people than ever before are reaching old age in better health and enjoying that health for a longer time. This Handbook outlines the latest discoveries in the study of aging from bio-medicine, psychology, and socio-demography. It treats the study of aging as a multidisciplinary scientific subject, since it requires the interplay of broad disciplines, while offering high motivation, positive attitudes, and behaviors for aging well, and lifestyle changes that will help people to stay healthier across life span and in old age. Written by leading scholars from various academic disciplines, the chapters delve into the most topical aspects of aging today - including biological mechanisms of aging, aging with health, active and productive aging, aging with satisfaction, aging with respect, and aging with dignity. Aimed at health professionals as well as general readers, this Cambridge Handbook offers a new, positive approach to later life.
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| Emner | |
| Sjanger | |
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| ISBN | 1-108-66072-X. - 1-316-67701-X
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