Biochemical Protozoology As A Basis For Drug Design
Graham H. Coombs
Bok Engelsk 1991 · Electronic books.
| Utgitt | Hoboken : : Taylor and Francis, , 1991.
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| Omfang | 1 online resource (656 p.)
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| Opplysninger | Description based upon print version of record.. - Book Cover; Title; Contents; Preface; Contributors; The current status of biochemical protozoology; The biochemistry of malaria: an overview; Pneumocystis carinii: potential targets for chemotherapeutic attack; Giardia cysts: their biochemistry and metabolism; The biochemical activities and importance of the ciliate protozoa in the rumen ecosystem; Energy metabolism of anaerobic parasitic protists; The effects of environmental factors on the metabolism of Giardia and Trichomonas; Energy metabolism in Giardia intestinalis; Amino acids catabolism in anaerobic protists. - Amoebapain, the major proteinase of pathogenic Entamoeba histolytica Proteinases of malaria parasites; Plasmodium proteinases during the erythrocytic phase of infection; Proteinases of Babesia; Glycosylated phosphatidylinositols of the trypanosomatidae; Structural variations of the leishmanial lipophosphoglycan; Lipid biochemistry of trypanosomatids; Lipids and lipid metabolism of trichomonads (Tritrichomonas foetus and Trichomonas vaginalis). - Approaches to investigating cation metabolism in malaria-infected erythrocytesCation-transporting ATPases of Plasmodium; Is the multidrug resistant protein of the malaria parasite involved in drug resistance?; S-Adenosylmethionine metabolism in parasitic protozoa; Methionine recycling as a target for antiprotozoal drug development; Polyamine metabolism in anaerobic protozoa; Polyamine metabolism in African trypanosomes; Trypanothione metabolism as a target for drug design: molecular modelling of trypanothione reductase. - Intermediary metabolism of Leishmania Glycosomes; Mitochondrial metabolism of African trypanosomes; Mitochondria of Plasmodium; Proteinases of mammals: an overview; Proteinases of parasitic protozoa: an overview; New approaches to molecular analysis of proteinases of parasitic protozoa; Proteinases of Trypanosoma cruzi; Proteinases of African trypanosomes; Cysteine proteinases of leishmanias; The promastigote surface proteinase of Leishmania; Proteinases of trichomonads and Giardia; The cysteine proteinase of Entamoeba histolytica: cloning of the gene and its role as a virulence factor. - Lipid composition of the membranes of malaria-infected erythrocytes and the role of drug-lipid interactions in the mechanism of action of chloroquine and other antimalarials Adaptation of Leishmania species to an acidic environment; Glucose uptake mechanisms as potential targets for drugs against trypanosomatids; Transport and compartmentation in Entamoeba histolytica; Substrate specificities for malaria-inducible red cell transport in relation to parasite metabolism; Nucleoside transport in malaria- and Babesia-infected cells. - The antioxidant enzymes glutathione reductase and trypanothione reductase as drug targets. - A compilation of articles on protozoological biochemistry which reviews the subject area and offers information on current research. Included in the Topics Covered Are Energy Metabolism Of Anaerobic Parasitic Protists, proteinases of African
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| ISBN | 1-135-75147-1
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