Apolipoprotein E and alpha(1)-antichymotrypsin genotypes and age ofonset of familial Alzheimer's dis - detaljert visning

Apolipoprotein E and alpha(1)-antichymotrypsin genotypes and age ofonset of familial Alzheimer's disease

K. Axelman
Bok Engelsk 1999


Utgitt	1999
Omfang	Side 1- 5
Opplysninger	Apolipoprotein E (APOE) and alpha(1)-antichymotrypsin (ACT) genotypeand allele frequency distribution were investigated in 113 familialAlzheimer's disease (AD) cases. A significantly higher epsilon 4frequency was observed in patients with an age of onset between 55-64and 65-74 years compared to individuals with later or earlier onset,No difference in ACT A allele frequency was seen in any onset group,nor was any influence of ACT genotypes on the age of onset observed,However, the mean age of onset was lowered by the presence of theACT/AA and ACT/TT genotypes among APOE epsilon 3/3 bearers. PossibleAPOE effects on age of onset were evaluated in 78 affected sib pairs.An earlier age of onset was observed in siblings with an epsilon 4allele compared to siblings without an epsilon 4 allele. Thissupports the notion that the epsilon 4 allele promotes an earlier ageof onset. However, in siblings with the same APOE genotype, a widerange of onset was seen, indicating that unknown genetic orenvironmental factors affect the expression of AD.
Emner	APOLIPOPROTEIN-E ASSOCIATION Age of onset Alpha-1-antichymotrypsin Vis mer... E ALLELE EPSILON-4 E POLYMORPHISM Familial Alzheimer`s Disease GENE OF-ONSET PATHOGENIC MUTATION POPULATION PRECURSOR PROTEIN MUTATION TYPE-4 ALLELE