Tau protein in cerebrospinal fluid: A new diagnostic and prognosticmarker in Alzheimer disease?
P. Mecocci
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 211- 214
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| Opplysninger | Tau is the main protein of paired helical filaments. It can bedetected and measured in cerebrospinal fluid (CSF) and for thisreason it has been proposed as a possible in vivo marker of Alzheimerdisease (AD). To evaluate the usefulness of CSF tau in the diagnosisof AD we measured it in patients with AD, frontal lobe dementia(FLD), vascular dementia (VD), and in healthy controls by means of aspecific enzyme-linked immunosorbent assay test. Individuals with ADhad significantly higher tau levels than FLD, VD, and controls.Individuals with late onset AD had significantly higher levels thanthose with early onset disease. In AD, CSF tau level did notcorrelate with age, duration, or severity of the disease, whereas acorrelation with age was found in FLD and controls. In the nine ADpatients in whom CSF tan measurement was repeated after 2 years, meanlevels did not differ from baseline, although a worsening ofcognitive performances occurred. The overlap among the differentgroups and the absence of any modification over time suggest that CSFtau measurement, more than in confirming or staging overt AD, mightbe useful in revealing the disease at its preclinical phase.
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| Emner |
