Are genetic factors important in the aetiology of leukoaraiosis?Results from a memory clinic population
K. Amar
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 585- 590
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| Opplysninger | Objective. To discover whether polymorphism in either theapolipoprotein E (ApoE) or angiotensin-converting enzyme (ACE) genesis associated with leukoaraiosis, white matter lesions visible onneuroimaging of the brain, which is commonly seen in dementia as wellas some normal elderly subjects.Design, Prospective study of consecutive patients attending ourmemory disorders clinic, to examine the relationship betweenleukoaraiosis and polymorphism of the ApoE and ACE genes.Setting. Memory disorders clinic in Bristol, UK.Patients. 182 patients attending the memory disorders clinic forinvestigation of possible dementia of whom 75% were suffering fromdementia, 20% from memory impairment but no dementia and in 5% ofwhom a dementing illness was thought to be unlikely; 38% of allpatients had visible white matter lesions and 16% had cerebralinfarcts.Measures. Patients and/or carers who agreed to participate in thestudy had their ACE and ApoE genotype determined and their brainCT/MRI scans were assessed by a neuroradiologist, blind to the resultof the genotyping, for the presence or absence of white matter lowattenuation.Results, There was a significant association between white matterlesions and the DD genotype (p < 0.05), but not the ApoE genotype.However, this relationship with the DD genotype was only significantfor patients with a previous infarct.Conclusion, Homozygosity of ACE gene deletion polymorphism is a riskfactor for white matter lesions when it is associated with cerebralinfarction, This suggests that it may be possible to identifysubjects who are at greater risk of developing white matter lesionsand are at risk of cognitive impairment and possibly dementia. (C)1998 John Wiley & Sons, Ltd.
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