Apo E and apo CI loci are associated with dementia in younger but notolder late-onset cases
C. Tysoe
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 191- 198
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| Opplysninger | Numerous groups have confirmed that apolipoprotein E allelicvariation accounts for a proportion of the genetic risk for late-onset Alzheimer's disease (AD), However, there is a paucity of dataon the impact of this locus on the overall risk of dementia (asopposed to AD) in the elderly. Most studies have ascertainedspecifically AD cases from hospital clinics or brain banks and manydemented cases have vascular dementia or mixed AD and vascularpathology. We have examined the closely linked apo E and apo CI lociin demented cases and non-demented controls from two community-basedaged Cambridgeshire populations: the rural fly population (cohort1)comprised 60 pairs of demented and non-demented elderlyindividuals, with a mean age of 84.2 years (SD = 6.11); the Cambridgecity population (cohort 2) comprised 81 pairs air aged over 84 with amean age of 87.7 years (SD = 2.9), The younger fly cohort showedsignificant allelic associations with dementia at the apo E and apoCI loci, which were not replicated in the older Cambridge cohort,These data suggest the possibility of age-dependent penetrance fordifferent candidate genes in late-onset dementia, We propose a numberof explanations to account for the stronger associations we observedbetween dementia and apo CI, compared to the neighbouring apo Elocus. Our data are compatible with the possibility that specificalleles or genotypes may confer different risks for overall dementia,compared to AD.
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| Emner |
