Reduced intraneuronal lipofuscin content in dementia with Lewy bodiescompared with Alzheimer's disease and controls
L.M. Drach
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 1- 5
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| Opplysninger | Lipofuscin has been of interest in dementia of Alzheimer's type(DAT), because of the hypothesis that dementia is a kind of prematureageing. The results of studies on intraneuronal lipofuscin content inDAT are inconsistent. At present no data on intraneuronal lipofuscinin dementia with Lewy bodies (DLB) are available. The amount oflipofuscin in the neurons of the inferior olivary nucleus of 10brains of DLB patients, 10 of age-matched DAT patients, and 10 of age-matched controls has been measured microfluorometrically. Theintraneuronal lipofuscin content in the DLB patients wassignificantly lower than in the DAT patients and controls. Thisfinding may indicate a general alteration of neuronal cell metabolismin DLB, e.g. A defect of mitochondrial DNA, not confined to neuronsdeveloping Lewy bodies.
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| Emner |
