Amygdala-hippocampal atrophy and memory performance in dementia ofAlzheimer type
R. Heun
Bok Engelsk 1997
| Utgitt | 1997
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| Omfang | Side 329- 336
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| Opplysninger | The aim of the present study was to examine the involvement of brainstructures, especially the amygdala-hippocampal complex, in dementiaof Alzheimer type (DAT), and to assess the relation of amygdala-hippocampal atrophy with memory dysfunction. 14 patients with DAT and10 healthy age-matched controls were examined with differentneuropsychologic tests including the UCLA-Auditory Verbal LearningTest. MRI was performed with a conventional 1.5-tesla scanner.Atrophy was found in many brain structures of demented subjects incomparison with healthy age-matched controls. The volumes of amygdala-hippocampal complexes and of the temporal lobes of demented subjectswere more reduced than the total brain volume and other structures.Memory dysfunction was highly correlated with atrophy of the amygdala-hippocampal complexes and of the temporal lobes. Consequently, DATseems to affect the amygdala-hippocampal complex and their relatedfunction (i.e. Memory) more than other cerebral structures, butcerebral degeneration in DAT is not restricted to these structures.
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| Emner |
