Aspirin, anti-inflammatory drugs and risk of dementia
A.S. Henderson
Bok Engelsk 1997
| Utgitt | 1997
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|---|---|
| Omfang | Side 926- 930
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| Opplysninger | Objective, To test the hypothesis that aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) may prevent dementia or cognitiveimpairment.Design. A two-wave longitudinal study over 3.6 years.Setting. A community survey of elderly persons living in Canberra,Australia.Participants. There were 1045 elderly persons aged 70 at the start ofthe study; cognitive assessment was obtained at both waves on 588.Main outcome measures, Cognitive functioning was measured using theMini-Mental State Examination, an episodic memory test, a test ofmental speed and the National Adult Reading Test, Dementia wasassessed using the Canberra Interview for the Elderly.Results, On cross-sectional data, those who had been taking NSAIDs oraspirin performed no better on the cognitive tests after account hadbeen taken of other confounding variables. There was no interactionwith apolipoprotein E genotype. On longitudinal data, no differencewas found between NSAID or aspirin users and controls, either incognitive decline or incidence of dementia.Conclusions, The results do not support the hypothesis that aspirinor NSAIDs have a protective effect, but it remains possible thatvarious sources of measurement error may have attenuated an effect ofclinical significance from either type of drug. Conclusive evidencecan be obtained only by a prospective trial, (C) 1997 John Wiley &Sons, Ltd.
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| Emner |
