Symptomatological characteristics distinguish between frontotemporaldementia and vascular dementia with a dominant frontal lobe syndrome
M. Sjögren
Bok Engelsk 1997
| Utgitt | 1997
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| Omfang | 5 s.
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| Opplysninger | Objective. Our hypothesis was that patients with vascular dementia and a dominating frontal lobe syndrome have a symptomatology that reflects a more widespread lesion compared with patients with frontotemporal dementia.Design. Patients with vascular dementia and a dominating frontal lobesyndrome (VAD-F; N=11) were compared with regard to clinical symptoms and imaging features on CT scans of the brain with patients with frontotemporal dementia (FTD; N=21).Setting. A neuropsychiatric diagnostic ward.Patients. Thirty-two inpatients, aged 45-78 years, with frontotemporal dementia or vascular dementia.Measures. Relatives were questioned about the initial symptoms, Arthe clinical investigation, mental and neurological symptoms and signs were recorded using the STEP method (stepwise comparativestatus analysis), CT-scan features of the brain were evaluated by a trained neuroradiologist. The GBS-i (Gottfries-Brane-Steen,intellectual variables) scale was used to measure the degree of dementia.Results. At the onset of dementia, loss of memory (p<0.001), sudden onset (p < 0.001), confusion (p < 0.05) and unspecified neurologicalsigns (p < 0.05) had been significantly more frequent in the VAD-Fgroup, At the time of the clinical investigation, lack of socialawareness and presence of primitive reflexes were more frequent in the FTD group (p < 0.01 and p < 0.05, respectively) and visuospatial deficits more frequent in the VAD-F group (p ( 0.05), CT of the brain showed that, apart from brain infarcts (present only in the VAD-Fgroup), paraventricular leukoaraiosis was significantly more pronounced in the VAD-F group (p < 0.05). The groups did not differ with respect to age, age at onset or level of dementia.Conclusion. The findings support our hypothesis.
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