Is a randomized trial of antioxidants in the primary prevention ofAlzheimer disease warranted?
D.A. Evans
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 45- 49
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| Opplysninger | Alzheimer disease is a common condition that severely affects bothpersons with the illness and their families. Prevention of Alzheimerdisease is an urgent priority, but study of potentially modifiablerisk factors for the illness is at an early stage. Laboratory studiessuggest that oxidative mechanisms may be involved in the pathogenesisof Alzheimer disease and raise the possibility that antioxidantnutrients could be used in disease prevention. Observational studiessuggest that antioxidant nutrients may have protective effectsagainst a number of other common chronic diseases, includingcardiovascular disease and cancer. Because the protective effects, ifany, of antioxidant nutrients are likely to be small to moderate inmagnitude, large-scale randomized trials of primary prevention willlikely be necessary to resolve this issue, and a major question ishow quickly to progress to expensive and time consuming trials neededto provide more definitive evidence. This is a difficult question,but the severity of the disease, the current absence of preventivestrategies and the likelihood that observational studies alone willnot provide clear resolution of the issue all suggest that it may beprudent to strongly consider such trials in the near future.
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| Emner |
