Do you mind standing? Cognitive changes in orthostasis
L.C. Perlmuter
Bok Engelsk 1996
| Utgitt | 1996
|
|---|---|
| Omfang | Side 325- 341
|
| Opplysninger | This initial study examines cognitive function in individuals withasymptomatic orthostatic hypotension. Cerebral hypoperfusionaccompanying repeated episodes of orthostatic hypotension. Mayeventually produce some cerebral structural deterioration which,depending on foci, could compromise cognitive function, Subjects(aged 55 to 74 years) were relatively healthy women and men, themajority of whom were being treated for non-insulin-dependentdiabetes mellitus. Blood pressure (BP) and pulse were measured undersupine and upright posture. The difference between BP and pulse undersupine and standing conditions indexed orthostatic hypotension. AboutI hr after evaluation of orthostatic hypotension, cognitive testingwas performed with individuals comfortably seated. Results showedthat, irrespective of possible confounders, including depression,decreased systolic BP in response to upright posture predicted slowerreaction times and compromised serial list learning, although sparingimmediate and working memory. Orthostatic hypotension, measurable inmore than 4% of the elderly, is a hitherto unexplored source ofcognitive decline.
|
| Emner |
