Lack of effect of tacrine administration on the anticoagulant activity of warfarin
P.A. Reece
Bok
| Utgitt | AJ Sedman Warner Lambert Parke Davis Parke Dav
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| Opplysninger | The effect of tacrine administration on prothrombin time was studied in 13 patients receiving prolonged warfarin therapy. After a 3-week baseline period and 5 days of placebo administration, patients received 20 mg tacrine four rimes daily for 5 days. Prothrombin times were determined during baseline, daily before the morning doses of placebo and tacrine, and 14 days after the last tacrine dose (closeout). Mean (+/- SD) prothrombin times were 16.2 +/- 2.8 seconds at baseline, 15.1 +/- 2.6 seconds during the placebo phase, 15.8 +/- 3.6 seconds during the tacrine phase, and 15.3 +/- 3.6 seconds at closeout, indicating that tacrine has no effect on the anticoagulant activity of warfarin, Alteration of warfarin dosage should not be required in patients receiving concurrent tacrine therapy.
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