Follow-up study of risk factors in progressive supranuclear palsy
L.I. Golbe
Bok Engelsk 1996
| Utgitt | 1996
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|---|---|
| Omfang | Side 148- 154
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| Opplysninger | The cause of progressive supranuclear palsy (PSP) is not known andhas been little studied. The one previous controlled epidemiologicsurvey, performed at our center in 1986, found small-town experienceand greater educational attainment as PSP risks, but, in retrospect,these results may have been produced by ascertainment bias. Sincethat time, several anecdotal reports have implicated heredity andvarious environmental exposures in the cause of some cases of PSP. Toclarify the results of the previous study and to evaluate the morerecently implicated candidate factors in a controlled fashion, wemailed a validated 69-item questionnaire to 91 personally examinedpatients with PSP and 104 unmatched controls with other neurologicconditions for which they had been referred to our tertiaryneurologic center. We were able to match 75 subjects from each groupby year of birth, sex, and race and subjected them to a separatematched-pair analysis. We allowed surrogates to supply any or all ofthe responses. Questions concerned hydrocarbon, pesticide, andherbicide exposure; urban/rural living; auto repair and otheroccupations; head trauma; educational attainment; maternal age; andfamily history of PSP, parkinsonism, dementia, and other neurologicconditions. A statistically significant finding was that patientswith PSP there less likely to have completed at least 12 years ofschool (matched odds ratio = 0.35, 95% CI = 0.12-0.95, p = 0.022;unmatched odds ratio = 0.44, 95% CI = 0.21-0.89, p = 0.020). Wehypothesize that this result may be a proxy for poor early-lifenutrition or for occupational or residential exposure to an as-yetunsuspected toxin. Future studies should examine these potential riskfactors in PSP.
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| Emner |
