The effects of nicotine in dermal plaster on cognitive functions inpatients with Alzheimer's disease
J. Snaedal
Bok Engelsk 1996
| Utgitt | 1996
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| Omfang | Side 47- 52
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| Opplysninger | Eighteen patients with probable Alzheimer's disease (NINCDS/ADRDAcriteria) participated in a placebo-controlled, double-blind study,with a crossover design. The patients had mild or moderate dementia(MMSE = 20.3 +/- 4.6, range 12-28). The trial consisted of two 4-weekperiods with a 2-week washout period in between. Nicotine was givenin the form of dermal plasters. Most of the patients tolerated thehighest doses of 21 mg nicotine/24 h, but some received 14 mg/24 h.The effect was monitored with tests of short-term memory, verbalfluency, attention and psychomotor speed. Nicotine was alsodetermined in the blood. Short-term memory improved significantlyafter 4 weeks of treatment, both on nicotine and placebo (p < 0.05/p< 0.01). The results of our study thus do not indicate that nicotineapplied in the form of dermal plasters is of any significance in thetreatment of memory deficits in patient with Alzheimer's disease.
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| Emner |
