A potential noninvasive neurobiological test for Alzheimer's diseasepotential
Leonard F.M. et al. Scinto
Bok Engelsk
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| Utgave | Kopi
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| Opplysninger | ABSTRACT: Currently Alzheimer's disease, which affects more than 20 million people worldwide, can only be definitively diagnosed by histological examination of brain tissue obtained at autopsy or biopsy. There is a great need for an early, noninvasive, sensitive, and easily administered diagnosis test of Alzheimer's disease. Here it is reported that patientsdiagnosed with probable Alzheimer's disease by standard clinical criteria exhibited a marked hypersensitivity in their pupil dilation response to a cholinergic antagonist, tropicamide, placed in their eyes. It was possible to distinguish 18 of 19 individuals (95%) either clinically diagnosed with Alzheimer's disease or classified as suspect Alzheimer's individuals by neuropsychological screening from 30 of 32 normal elderly controls (94%).
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