Smoking and Alzheimer's disease: A review of the epidemological evidence
P.N. Lee
Bok Engelsk 1994
| Utgitt | Basel : Karger , 1994
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| Omfang | 14 s.
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| Utgave | Særtrykk
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| Opplysninger | ABSTRACT: Overall evidence from 19 case-control studies of Alzheimer's disease (AD) and smoking shows a highly significant (p<0.001) negative association 8ever/never smokers, relative risk (RR) 0.64, 95% confodence interval (CI) 0.54-076]. Some studies have apparent design faults but the association is clearly evident in those which do not (RR 0.60, 95%CI 0.46-078). A report of a positive relationship from a prospective study can be dismissed due to unreliability of AD diagnosis on death certificates, andd other study weaknesses. Although more data are needed on dose response and to rule out possible confounding, the negative association is consistent with other data suggesting nicotine protects against AD.
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