Dynamics of the Mammalian Sperm Head
Kiyotaka. Toshimori
Bok Engelsk 2009 · Electronic books.
| Annen tittel | |
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| Utgitt | Dordrecht : : Springer, , 2009.
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| Omfang | 1 online resource (106 p.)
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| Opplysninger | Description based upon print version of record.. - CONTENTS; 1 Introduction; 2 Mammalian Sperm Head; 2.1 Structures, Domains, and Related Functions; 2.2 Cytoplasmic Layers; 2.2.1 Periacrosomal and Subacrosomal Layers; 2.2.2 Postacrosomal Layer; 2.3 Membrane System; 3 Sperm-Head Formation and Factors Affecting It; 3.1 Cellular Interactions; 3.1.1 Stem-Cell Factor, Steel Factor, and the c-kit Receptor; 3.1.2 Intercellular Bridges; 3.1.3 Ectoplasmic Specialization; 3.2 IgSF Proteins; 3.2.1 IgSF Proteins Expressed on Sertoli Cells; 3.2.2 IgSF Proteins Expressed on Germ Cells. - 4 Post-testicular Modifications and Maturation Events Occurringin the Sperm Head4.1 In the Epididymis; 4.2 In the Female Reproductive Tract; 5 Dynamics of the Acrosome; 5.1 Acrosome Biogenesis During Spermatogenesis; 5.1.1 Golgi Phase (Steps 1-3 in Mice, Sa in Humans); 5.1.2 Cap Phase (Steps 4-7 in Mice, Sb1-2 in Humans); 5.1.3 Elongation Phase or Acrosome Phase (Steps 8-12 in Mice, Sc in Humans); 5.1.4 Maturation Phase (Steps 13-16 in Mice; Sd1-2 In Humans); 5.2 Pathways for the Transport of Acrosomal Molecules; 5.3 Microenvironment of the Acrosome. - 5.4 Post-testicular Modifications and Maturation Events5.4.1 Acrosomal Membrane; 5.4.2 Acrosomal Matrix; 5.4.3 Subcompartments; 5.5 Acrosomal Enzymes and Other Molecules; 5.6 Failure of Acrosome Biogenesis; 6 Dynamics of the Perinuclear Theca; 6.1 Biogenesis During Spermatogenesis; 6.2 Functions of Perinuclear Theca-Associating Molecules; 7 Dynamics of the Sperm Nucleus; 7.1 Formation and Maturation of the Nucleus; 7.2 Abnormal Nucleus Formation in Gene-KO Mice; 7.3 DNA Fragmentation; 7.3.1 DNA Damage in Germ Cells and Mature Spermatozoa; 7.3.2 Evaluation of DNA Fragmentation. - 8 Dynamics of the Membrane System8.1 Modifications in Sperm Plasma-Membrane Proteins; 8.2 Zona Pellucida Binding and the Acrosome Reaction; 8.3 Primary Binding of Sperm to the Zona Pellucida; 8.4 The Acrosome Reaction; 8.5 Rapid and Slow Release of Acrosomal Molecules; 8.6 Secondary Binding to the Zona Pellucida and the CandidateMolecules Involved; 8.7 Priming for Gamete Membrane Fusion and the CandidateMolecules Involved; 8.8 Gamete Membrane Fusion; 9 Dynamics of Egg (Oocyte) Activation; 9.1 Sperm (Cytoplasmic) Factor and Candidate Molecules Involved in Egg Activation; 9.2 Sperm Receptor. - 9.3 After Egg Activation10 Status of Sperm-Head Components During Normal Fertilization,IVF, ICSI, and Round Spermatid Injection; 11 Conclusion; References; Index. - In humans, male infertility is caused by a number of factors such as the external environment, nutrient changes, genotoxins, and mutagens. This book discusses the events that occur in the normal sperm head and govern the structure-function relationship from the time of spermatogenesis to that of fertilization or egg activation.
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| Emner | |
| Sjanger | |
| Dewey | |
| ISBN | 9783540899785
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