Enzyme Kinetics : Catalysis & Control : A Reference of Theory and Best-Practice Methods


Daniel L. Purich
Bok Engelsk 2010 · Electronic books.
Utgitt
Burlington : : Elsevier Science, , 2010.
Omfang
1 online resource (915 p.)
Opplysninger
Description based upon print version of record.. - Front Cover; Enzyme Kinetics:Catalysis & Control; Copyright; Contents; Preface; Chapter 1An Introduction to Enzyme Science; CATALYSIS; BIOLOGICAL CATALYSIS; DEVELOPMENT OF ENZYME KINETICS; THE CONCEPT OF A REACTIONMECHANISM; EXPLAINING THE EFFICIENCY OF ENZYME CATALYSIS; PROSPECTS FOR ENZYME SCIENCE; FURTHER READING; Chapter 2Active Sites and their Chemical Properties; ENZYME ACTIVE SITES; FORCES AFFECTING ENZYME STRUCTURAL STABILITY AND INTERACTIONS; ACTIVE-SITE DIVERSIFICATION; ADDITIONAL FUNCTIONAL GROUPS IN ENZYME ACTIVE SITES; METAL IONS IN ENZYME ACTIVE SITES. - ACTIVE SITES OF ENZYMES ACTING ON POLYMERIC SUBSTRATESBASIC ORGANIC CHEMISTRYOF ENZYME ACTION; DETECTING COVALENT INTERMEDIATES IN ENZYME REACTIONS; BASICS OF ENZYME STEREOCHEMISTRY; ELECTRON TRANSFER REACTIONS; FURTHER READING; APPENDIX: ACCESSING ENZYMESTRUCTURES; Chapter 3Fundamentals of Chemical Kinetics; TIMESCALE OF CHEMICAL PROCESSES; THE EMPIRICAL RATE EQUATION; REACTION RATE, ORDERAND MOLECULARITY; BASIC STRATEGIES FOR EVALUATING RATE PROCESSES; COMPOSITE MULTI-STAGE (MULTI-STEP) MECHANISMS; THERMAL ENERGY: THE BOLTZMANN DISTRIBUTION LAW; SOLUTION BEHAVIOR OF REACTING MOLECULES. - APPENDIX: ENZYMES WITH DEFINEDMULTISUBSTRATE KINETIC MECHANISMS. - EQUILIBRIUM CONSTANT DETERMINATIONSCONCLUDING REMARKS; FURTHER READING; Chapter 5Initial-Rate Kinetics of One-Substrate Enzyme-Catalyzed Reactions; MICHAELIS-MENTEN TREATMENT; THE BRIGGS-HALDANE STEADY-STATE TREATMENT; CATALYSIS INVOLVING TWOOR MORE INTERMEDIATES; ADDITIONAL COMMENTS ON FUNDAMENTAL KINETIC PARAMETERS; REACTION PROGRESS CURVE ANALYSIS; RIBOZYME KINETICS; PROTEASOME KINETICS; ISOMERIZATION MECHANISMS; SIMULTANEOUS ACTION OF AN ENZYME ON DIFFERENT SUBSTRATES; ENANTIOMERIC ENRICHMENTAND ANOMERIC SPECIFICITY; SIMULTANEOUS ACTION OF TWO ENZYMES ON THE SAME SUBSTRATE. - INDUCED-FIT MECHANISMSKINETICS OF ENZYMES ACTINGON POLYMERIC SUBSTRATES; CONCLUDING REMARKS; FURTHER READING; Chapter 6Initial-Rate Kinetics of Multi-Substrate Enzyme-Catalyzed Reactions; BISUBSTRATE KINETIC MECHANISMS; DERIVATION STEADY-STATE BISUBSTRATE RATE EQUATIONS; DERIVATION OF RAPID EQUILIBRIUM BISUBSTRATE RATE EQUATIONS; PING PONG BI BI MECHANISM; GRAPHICAL AND QUANTITATIVE ANALYSIS OF BISUBSTRATE KINETICS; THREE-SUBSTRATE ENZYME KINETICS; MULTISUBSTRATE ''ISO'' MECHANISMS; KINETIC PROPERTIES OF ENZYMESEXHIBITING BRANCHED TRANSFERPATHWAYS; CONCLUDING COMMENTS. - TRANSITION-STATE THEORYCHEMICAL CATALYSIS; REACTION COORDINATE DIAGRAMS; THERMODYNAMIC PRINCIPLES; CONCLUDING REMARKS; FURTHER READING; Chapter 4Practical Aspects of Measuring Initial Rates and Reaction Parameters; DESIGN OF INITIAL-VELOCITY ENZYME ASSAYS; ENZYME PURIFICATION; COUPLED (OR AUXILIARY) ENZYME ASSAYS; BASIC UV/VISIBLE ABSORPTION SPECTROSCOPY; BASIC FLUORESCENCE SPECTROSCOPY; MEASURING REACTION RATESWITH ISOTOPES; MULTISUBSTRATE KINETICSAND INHIBITOR KINETICS; ANALYSIS OF ENZYME RATE DATA; WORKING WITH ATP-DEPENDENT ENZYMES; REGENERATING NUCLEOSIDE59-TRIPHOSPHATE SUBSTRATES. - Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also
Emner
Sjanger
Dewey
ISBN
9780123809247

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