Research Priorities for Chagas Disease Human African Trypanosomiasis and Leishmaniasis : TDR Disease Reference Group on Chagas Disease Human African Trypanosomiasis and Leishmaniasis.
World Health. Organization
Bok Engelsk 2012 · Electronic books.
| Omfang | 1 online resource (114 pages)
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| Opplysninger | Cover -- Contents -- WHO/TDR Disease Reference Group on Chagas Disease, Human African Trypanosomiasis and Leishmaniasis -- Abbreviations and acronyms -- Executive summary -- 1. Introduction -- 1.1 Reasons for setting research priorities -- 1.2 TDR stewardship mandate -- 1.3 Goal of this report /strategic objectives -- 1.4 Overview -- 2. Methodology and prioritization -- 2.1 Authoritative evidence review to define thematic areas -- 2.2 Stakeholders' consultation and second round of criteria-based ranking -- 2.3 Final round of ranking -- 3. Epidemiology and burden of disease -- 3.1 Chagas disease -- 3.2 Human African trypanosomiasis -- 3.3 Leishmaniasis -- 4. Clinical forms, pathogenesis and HIV coinfection -- 4.1 Chagas disease -- 4.1.1 Clinical presentations -- 4.1.2 Chagas heart disease -- 4.1.3 Gastrointestinal manifestations -- 4.1.4 Congenital Chagas disease -- 4.1.5 Chagas disease and HIV coinfection -- 4.2 Human African trypanosomiasis -- 4.2.1 Pathogenesis -- 4.2.2 Clinical presentation -- 4.3 Leishmaniasis -- 4.3.1 Clinical presentations -- 5. Diagnosis -- 5.1 Chagas disease -- 5.1.1 Parasitological diagnosis -- 5.1.2 Serology -- 5.1.3 Quantitative and qualitative detection of parasite DNA -- 5.1.4 Diagnosis in newborns -- 5.1.5 Diagnosis of therapy efficacy and cure -- 5.1.6 Diagnosis of drug resistant Chagas disease -- 5.2 Human African trypanosomiasis -- 5.2.1 Demonstration of parasite -- 5.2.2 Serology -- 5.2.3 Quantitative and qualitative detection of parasite DNA -- 5.2.4 Staging of the disease -- 5.3 Leishmaniasis -- 5.3.1 Parasitological diagnosis -- 5.3.2 Serology -- 5.3.3 Detection of parasite products -- 5.3.4 Quantitative and qualitative detection of parasite DNA -- 6. Drugs and drug resistance -- 6.1 Current treatment and development of new drugs -- 6.1.1 Chagas disease -- 6.1.2 Human African trypanosomiasis.. - 6.1.3 Leishmaniasis -- 7. Vaccines against Chagas disease, human African trypanosomiasis and leishmaniasis -- 7.1 Overview -- 7.2 Chagas disease -- 7.3 Human African trypanosomiasis -- 7.4 Leishmaniasis -- 8. Vector control -- 8.1 Chagas disease: triatomine bug control -- 8.2 Human African trypanosomiasis: tsetse fly control -- 8.2.1 Tsetse species of highest priority -- 8.2.2 Control activities at all levels -- 8.2.3 Costs of vector control -- 8.3 Leishmaniasis: sandfly control -- 8.3.1 Source reduction -- 8.3.2 Targeting sugar-feeding adult sandflies -- 8.3.3 Extermination of sandflies feeding on domestic animals -- 8.3.4 Flight barriers for preventing sandflies from reaching houses -- 8.3.5 Protection of homes - indoor residual insecticide spraying -- 8.3.6 Protection of rooms/porches - insecticide diffusers and coils -- 8.3.7 Personal protection - insecticide-treated nets and repellents -- 8.3.8 Integrated disease-control campaigns -- 9. Economic evaluation of health-care interventions -- 10. Research priority recommendations -- Acknowledgements -- References -- Appendices.. - The Disease Reference Group on Chagas Disease Human AfricanTrypanosomiasis and Leishmaniasis (DRG3) was part of an independent thinktankof international experts established by the Special Programme for Researchand Training in Tropical Diseases (TDR) to identify key research prioritiesthrough systematic review of research evidence and input from stakeholders.These three distinct insect-borne diseases while caused by related kinetoplastidprotozoan pathogens have dissimilar geographical distributions a reflection oftheir different insect vectors and range of vector contact with humans. Thediseases disproportionately afflict poor and remote populations with limitedaccess to health services; the pathogenic mechanisms are poorly understood buttypically entail immunological processes.
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| ISBN | 92-4-068999-0
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