Proteins of the Cerebrospinal Fluid : Analysis & Interpretation in the Diagnosis and Treatment of Neurological Disease
Edward J. Thompson
Bok Engelsk 2005 · Electronic books.
| Utgitt | Burlington : : Elsevier Science, , 2005.
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| Omfang | 1 online resource (353 p.)
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| Opplysninger | Description based upon print version of record.. - Chapter 1 Brief historical review of CSF proteins; Introduction; Investigators of CSF proteins; Part 1 Normal CSF proteins, an overview; Chapter 2 Functional glossary; Introduction; Immunoglobulin synthesis; Barrier terms; Chapter 3 The roster of CSF proteins; Introduction; Amounts; Functions; Chemical groups: molecular properties; Molecular properties: size; Molecular properties: charge; Chapter 4 Differences between proteins in CSF and serum; Introduction; Quantitative; Higher absolute levels due to obvious synthesis within the CNS. - Higher relative levels due to selective entry into the CSF and/or local synthesisQualitative; Chapter 5 Different blood-CSF barriers; Introduction; Different sources of CSF proteins; Conclusion; Chapter 6 Qualitative versus quantitative analysis; Introduction; Pros and cons; Discrepancy between qualitative versus quantitative amounts; Conclusion; Part 2 Normal CSF proteins, detailed discussion; Chapter 7 Methodologies and their limitations; Introduction; General methods; Separation; Visualization; Quantification; Radiolabeled proteins; Chapter 8 Fitting the data to curves; Introduction. - Mathematics of the multiple sources of CSF proteinsConclusion; Chapter 9 Normal blood-CSF barrier values; Introduction; Expressions of values for normal data; Degrees of biologic variability; Critique of CSF immunoglobulin levels; Part 3 Individual diseases, and the future; Chapter 10 CNS immunoglobulin synthesis; Introduction; Efficient diagnosis; Differential diagnosis; Specific antigens; Technology; General methods for protein separation/visualization; Separation by isoelectric focusing; Antigen-specific immunoblotting; Dot-blots; Relative specific antibody on Eastern blots; CSF versus MRI. - Serum source of CSF antibodiesFocusing of serum and parallel CSF; Differential diagnosis of serum bands; Serum oligoclonal bands in MS; Paraneoplastic serum and CSF antibodies; Conclusion; Chapter 11 Non-immunoglobulin proteins; Introduction; Serum proteins modified within the CNS; Readily visualized proteins; Haptoglobin polymers; Tau protein (beta-2 transferrin); Group components; Orosomucoid; Paraprotein; Alpha-1-antitrypsin; Prealbumin (transthyretin); Alpha-2-macroglobulin; Proteins better demonstrated by immunofixation; C-Reactive protein; Complement components. - The 14-3-3 protein. - Unbound (free) immunoglobulin light chainsFibrinogen degradation products; 'Brain-specific' proteins in the CSF; Myelin basic protein; Enolase (14-3-2, gamma isoenzyme: neuronal); Glial fibrillary acidic protein (GFAP, alpha albumin, astroprotein); D-2 antigen (N-CAM protein); I-CAM protein; S-100 protein (a calcium-binding protein); Myelin associated glycoprotein (MAG); Major oligodendrocyte glycoprotein (MOG); Proteolipid protein (PLP); Ferritin (intracellular iron binding protein); Creatine kinase (CPK, BB isoenzyme); Tau protein; Neurofilament protein (heavy, light and phosphorylated). - The analysis of the protein content of the Cerebrospinal Fluid (CSF) is a central tool in the diagnosis of a number of diseases, including Multiple Sclerosis and Encephalitis. This book is a complete revision of the first edition published 16 years ago and reflects the advances in the field in that period. Containing the most comprehensive reference list available today with over 1300 references cross-indexed according to topics, it also includes many classical works that cannot be easily found through the public literature database (like PubMed). This book covers new areas of research such as
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| ISBN | 0123693691
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