Late Life Depression and Structural Brain Changes - A Review of Recent Magnetic Resonance Imaging Research
R.C. Baldwin
Bok Engelsk
| Utgitt | RC Baldwin Manchester Royal Infirm Oxford Rd
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| Opplysninger | SUMMARY: Recent findings using magnettic resonance imaging to investigate late life depression have reported an unexpectedly high prevalence of white matter and othe structural brain changes, suggesting a possible organic aetiology to the disorder in a proportion of cases. These findings are examined critically and it is concluded that their significance is not yet clear, although they may reflect underlying cerebrovascular change. A lack of postmortem data constitutes a major deficiency in this area of enquiry. An approach combining structural and dynamic imaging with postmortem examination would be the best strategy for future research.
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