Vitamin E and vitamin C supplement use and risk of incident Alzheimerdisease
M.C. Morris
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 121- 126
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| Opplysninger | Oxidative stress may play a role in neurologic disease. The presentstudy examined the relation between use of vitamin E and vitamin Cand incident Alzheimer disease in a prospective study of 633 persons65 years and older. A stratified random sample was selected from adisease-free population. At baseline, all vitamin supplements takenin the previous 2 weeks were identified by direct inspection. Afteran average follow-up period of 4.3 years, 91 of the sampleparticipants with vitamin information met accepted criteria for theclinical diagnosis of Alzheimer disease. None of the 27 vitamin Esupplement users had Alzheimer disease compared with 3.9 predictedbased on the crude observed incidence among nonusers (p = 0.04) and2.5 predicted based on age, sex, years of education, and length offollow-up interval (p = 0.23). None of the 23 vitamin C supplementusers had Alzheimer disease compared with 3.3 predicted based on thecrude observed incidence among nonusers (p = 0.10) and 3.2 predictedadjusted for age, sex, education, and follow-up, interval (p = 0.04).There was no relation between Alzheimer disease and use ofmultivitamins. These data suggest that use of the higher-dose vitaminE and vitamin C supplements may lower the risk of Alzheimer disease.
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| Emner |
