Copper, ceruloplasmin and superoxide dismutase in patients withAlzheimer's disease - A case-control study
J. Snaedal
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 239- 242
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| Opplysninger | The copper-containing enzyme superoxide dismutase (SOD) is a keyenzyme in suppressing the amounts of superoxide anion radicals.Ceruloplasmin, the copper-transporting protein in plasma, alsopossesses an important redox capacity. In this study the levels ofcopper and ceruloplasmin as well as SOD-activity and ceruloplasminoxidative activity were analyzed in order to throw some light onpossible defects in copper mechanisms in patients diagnosed withAlzheimer's disease (AD). The study included 44 patients with AD andtheir healthy age- and gender-matched controls. No difference ofsignificance was seen when comparing the copper or ceruloplasminconcentration in plasma of AD patients to that of their pairedcontrols. The SOD activity in red blood cells was significantly lowerin the patients than in their controls (p = 0.019). The ceruloplasminoxidative activity in plasma of Alzheimer's patients was greatlyreduced as compared to that of age- and gender-matched controls andthe difference was highly significant (p = 0.0005). Ceruloplasminactivity and SOD activity were not found to be intrinsicallycorrelated, It was postulated that reduced oxidative activity ofceruloplasmin in plasma might be either a cause or a consequence ofAD and that reduced SOD activity might further add to the oxidativedisturbances in AD due to defective ceruloplasmin activity.
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| Emner |
