Depression and Parkinson's disease: A review
Jeffrey L. Cummings
Bok Engelsk 1992
| Utgitt | 1992
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| Omfang | 12 s.
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| Utgave | Kopi
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| Opplysninger | OBJECTIVE: The purpose of this review is to provide an update of the research regarding depression in Parkinson's disease an dto synthesize the information into a neurobiological model relating the structural and biochemical changes in this disorder to the behavioral manifestations. METHOD: The author used a computer-based search of the literature, augmented by extensive bibliography-guided article reviews, to find information on depression an dParkinson's disease.FINDINGS: Depression occurs in approximately 40% of patients with Parkinson's disease; depression in Parkinson's disease is distinguished from othe dpressive disorders by greater anxiety and less self-punitive ideation. Lower CSF levels of 5-hydroxyindoleacetic acid, a past history of depression , and greater functional disability are associated with a greater risk of depression in Parkinson's disease. Female gender, early age at onset of Parkinson's disease, and greater left brain involvement may also be risk factors. Approximately half of depressed patients with Parkinson's disease with prominent bradykinesia and gait instability than in tremor-dominant syndromes. Depressed patients with Parkinson's disease have greater frontal lobe dysfunction and gretaer involvement of dopaminergic and noradrenergic systems than non-depressed patients with the disease. Mood changes in Parkinson's disease respond to treatment with conventional tricyclic antidepressants or ECT.CONCLUSIONS: Neuribiological investigations suggest that depressionin Parkinson's disease may be mediated by dysfunction in mesocortical/prefrontal reward, motivational, and stress-response systems. Neuropsychological, metabolic, clinical, pharmalogical, and anatomical studies support the involvement of frontal dopaminergic projections in patients with Parkinson's disease and depression.
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