Tardive dyskinesia in a chronically institutionalized population ofelderly schizophrenic patients: Prevalence and association withcognitive impairment
W. Byne
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 473- 479
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| Opplysninger | Background. Chronically hospitalized geriatric inpatients withschizophrenia are at particular risk for both tardive dyskinesia (TD)and cognitive impairment but have been insufficiently studied in thisregard. Similarly, the relationship between TD and cognitiveimpairment has not been adequately addressed in this population.Objectives. (1) To determine the prevalence of TD in a cohort ofchronically institutionalized schizophrenic geriatric inpatients. (2)To examine the relationship between the manifestations of TD invarious body regions and several potentially related variablesincluding current pharmacological regimen, age, age at firsthospitalization and cognitive status.Method. TD was assessed by the Modified Simpson Dyskinesia Scale andcognitive status by the Mini-Mental State Examination (MMSE). Therelationship between manifestations of TDI and other variables wasexamined by t-tests, ANOVA, MANOVA and correlational analysis.Results. The prevalence of TD was 60%. Prevalence increased with agebut was not related to current antipsychotic or anticholinergicregimen. Mean MMSE score did not differ between groups of patientswith and without TD as defined by the criteria of Schooler and Kane(1982); however, the mean MMSE score was significantly (p < 0.004)lower in subjects with orofacial TD as defined by Waddington andYoussef(1996), and the difference was not entirely accounted for bythe older age of the latter group.Conclusions. TD and cognitive impairment both increase with age.However, TD alone does not account for the severity of cognitiveimpairment in this population. The present study provides furthersupport for the hypothesis that the correlation between TD andcognitive impairment holds primarily for the orofacial manifestationsof TD. (C) 1998 John Wiley & Sons, Ltd.
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