beta-amyloid plaques: Stages in life history or independent origin?
R.A. Armstrong
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 227- 238
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| Opplysninger | Several types of discrete beta-amyloid (A beta) deposit or senileplaque have been identified in the brains of individuals withAlzheimer's disease and Down's syndrome. The majority of theseplaques can be classified into four morphological types: diffuse,primitive, classic and compact. Two hypotheses have been proposed toaccount for these plaques. Firstly, that the diffuse, primitive,classic and compact plaques develop in sequence and represent stagesin the life history of a single plaque type. Secondly, that thedifferent A beta plaques develop independently and therefore, uniquefactors are involved in the formation of each type. To attempt todistinguish between these hypotheses, the morphology, ultrastructure,composition, and spatial distribution in the brain of the four typesof plaque were compared. Although some primitive plaques may developfrom diffuse plaques, the evidence suggests that a unique combinationof factors is involved in the pathogenesis of each plaque type and,therefore, supports the hypothesis that the major types of A betaplaque develop independently.
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| Emner |
