Assessment of progression and prognosis in 'possible' and 'probable'Alzheimer's disease
G.R.J. Swanwick
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 331- 335
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| Opplysninger | Objective. The objective of this study was to assess the rate ofprogression and clinical predictors of decline in subjects with'possible' and 'probable' Alzheimer's disease (AD).Design/setting. The annual rate of change (ARC) forcognitive/functional scales was calculated for 95 subjects with ADattending a memory clinic. Two consecutive ARCs were calculated for asubgroup of 39 subjects.Results. The ARCs were relatively normally distributed; however,there was a large degree of variability. Neither age nor duration ofsymptoms at presentations were predictive of the rate of decline.However, the data suggested an effect of gender, with males having agreater rate of decline in cognition (p = 0.02). Finally, the rate ofprogression over the first year did not predict the subsequent ARC (p= 0.25).Conclusions. The high variability in ARCs observed in this study andpoor correlation between consecutive ARCs suggest that neither meanARC values nor the previous rate of decline can be used to aidclinicians in the assessment of response to acetylcholinesteraseinhibitors or other specific treatments for AD. (C) 1998 John Wiley &Sons, Ltd.
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