The expression of presenilin-1 mRNA in skin fibroblasts fromAlzheimer's disease
K. Ikeda
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 145- 148
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| Opplysninger | The presenilin-1 (PS-1) gene was recently identified as one of thecausative genes in the early onset of familial Alzheimer's disease(AD). Analysis of the PS-1 gene is thought to be useful in clarifyingthe pathogenesis of AD. However, there have been few reports aboutthe expression of the PS-1 gene in AD. In this study, we analyzed theexpression of PS-1 mRNA in cultured skin fibroblasts taken fromliving patients with AD by Northern blot analysis. The subjectsconsisted of 18 cases with AD and 10 cases of neurological patientswithout dementia (CTL). We found that the PS-1 mRNA levels in AD weresignificantly higher than those in CTL (p < 0.01). Moreover, we foundthat the PS-1 mRNA level increases in the early stages of AD andtends to decrease in the advanced stages. These findings suggest thathigh levels of PS-1 mRNA may play an important role in developing AD.
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| Emner |
