Platelet monoamine oxidase B activity in dementia - A 4-year follow-up
M.E. Gotz
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 74- 77
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| Opplysninger | Platelet monoamine oxidase B (MAO-B) activity has been found toincrease significantly in demented patients, For the first time, a 4-year follow-up of platelet MAO-B activity and Mini-Mental State (MMS)was performed in patients with probable dementia of the Alzheimertype (DAT) and age-matched controls, MAO-B activity of DAT patientsincreased significantly 2 years after the beginning of the study ascompared with controls and remained significantly higher for theentire period of the examinations (p < 0.0001), The decrease of theMMS scores did not correlate with the time course of the increase ofplatelet MAO-B activity (Spearman rank correlation test), The declineof the MMS scores of DAT patients preceded the elevation of MAO-Bactivity, Since degenerative processes in brain areas which areresponsible for cognitive function and are reflected by the MMSscores rather affect cerebral cholinergic than monoaminergicneurotransmitter systems, degeneration of the latter at late stagesof DAT might be reflected by increased platelet MAO-B activity.
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