Cerebral blood flow in white matter is correlated with systolic bloodpressure and EEG in senile dementia of the Alzheimer type
A. SiennickiLantz
Bok Engelsk 1998
| Utgitt | 1998
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| Omfang | Side 29- 38
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| Opplysninger | The presence and functional significance of white matter lesions inthe ageing brain and in dementia as well as their relation to bloodpressure are often discussed. The aim of this study was to evaluatecerebral blood flow in white matter (WMCBF) and its relation tosystemic blood pressure and multichannel EEG. WMCBF was measured in24 elderly women with senile dementia of Alzheimer's type (SDAT,median age 85.5, range 68-93) and 20 age-matched controls (median age86.0, range 79-93) using Tc-99m-HMPAO single photon emission CT. Asignificant low WMCBF could be observed in all analysed regions inSDAT subjects compared to controls, with the greatest decline in theposterior region (parietotemporo-occipital area). Correlationsbetween quantified EEG from the posterior regions and WMCBF wereseen. Systolic blood pressure was significantly lower in the SDATgroup and was positively correlated with WMCBF in the posterior andanterior brain regions. Whether low systemic blood pressure is theresult of cerebral dysfunction is unclear.
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| Emner |
