Effects of aging and dementia on the levels of thiobarbituric-acid-reactive products stimulated by L-glutamic acid in human autopsy andbiopsy brain tissue
Z. Kristofikova
Bok Engelsk 1998
| Utgitt | 1998
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|---|---|
| Omfang | Side 6- 12
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| Opplysninger | Basal and stimulated (by L-glutamic acid, GA) levels ofthiobarbituric-acid-reactive products were estimated in the braintissue (hippocampus, cortex and cerebellum) from autopsy samples ofpeople with Alzheimer disease (AD), multi-infarct dementia (MID) andfrom nondemented control patients. The experiment was also performedon biopsy brain tissue (cortex) of nondemented controls. The biopsybrain tissue influenced by normal aging in vivo showed a limitedsusceptibility to undergo lipid peroxidation stimulated by GA invitro in comparison with the younger tissue. A significant decreasein the ratio of stimulated to basal levels was found in thecerebellum of MID patients in comparison with nondemented controlsand AD patients.
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| Emner |
