Five-year incidence and prediction of dementia and cognitive declinein a population sample of women aged 70-79 at baseline
C. Brayne
Bok Engelsk 1997
| Utgitt | 1997
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| Omfang | Side 1107- 1118
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| Opplysninger | Objective. To determine the incidence of dementia and cognitivedecline and their predictors in a population Sample.Settings. A rural geographically defined population served by asingle health centre.Sample. 75% of the 70-74-year-old, 100% of the 75-79-year-old womenregistered with the practice.Method. Interview the total sample using an augmented version ofCAMDEX, including informant interview, and reaction times at baselineand 5 years later. IQ was estimated at baseline only.Results: 365 women were interviewed at baseline, 237 at follow-up.Incidence of dementia of all severities was 3.1% per annum (95% CI,2.2-4.3). CAMCOG declined by 12.6 points in those who becamedemented, MMSE by 3 points. Observed, self-reported and informant-reported cognitive difficulty at baseline all predicted laterincidence of dementia. The additional use of estimated IQ andreaction times did not increase the efficiency of either cross-sectional detection of dementia or prediction of dementia at 5years.Conclusions. The incidence of dementia was in the range reported byother studies; slight cognitive decline was noted in the totalpopulation, increasing with age and marked in incident dementia. Ofclinical importance was the finding that both the individuals and theinformants of those who subsequently demented were aware of decline 5years earlier. Simple and relatively easily administered cognitivetests were found to be the most efficient method of detection ofdementia. (C) 1997 John Wiley & Sons, Ltd.
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