Effects of serum vitamin B12 and folate status on episodic memory perfromance in very old age: A population-based study
Åke Wahlin
Bok Engelsk 1996
| Utgitt | Stockholm : Karolinska Institutet , 1996
|
|---|---|
| Omfang | 22 s.
|
| Utgave | Artikkel i bok
|
| Opplysninger | Running head: Vitamin status and episodic memory ion very old age. - ABSTRACT: We examined the relationship between low levels of serum vitamin B-12(<200pmol/liter) and folic aid(<11 nmol/lietr), separately or combined, and episodic memory perfromance in very old age. Subjects with low serum vitamin values were compared with a control group, matched on age and educational level. The population-based study sample (N=259) was selected from a group of non-demented community-dwelling persons in the age-range of 75-96 years.Episodic memory was tested by meansof free recall and recognition of slowly and rapidly presented words. results indicated a deteroriation in both free recall and recognition as a function of serum vitamin status. This deterioration was most pronounced in subjects with low levels of both vitamin B-12 and folic acid, although subjects with low levels and folic acid alone were also impaired. The vitamin-related deficit in free recall was attributable to secondary memory; no group differences were seen for primary memory, However, when vitamin levels were used as continuous variables in linear regression, no effects on memory were observed, idicating that B-12 and folic acid was speculated that the vitamin-relkated memory deficit may reflect encoding problems, possible due to alterations in brain metabolism. Yet, all groups benefited from decreased task pacing and copy cues (recognition), suggesting that vitamin status may not affect the ability to utilize cognitive support in episodic memory.
|
| Emner | |
| ISBN | 91-628-1860-0
|
