Staging of Alzheimer-type pathology: An interrater-intrarater study
Z. Nagy
Bok Engelsk 1997
| Utgitt | 1997
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|---|---|
| Omfang | Side 248- 251
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| Opplysninger | The staging method proposed by Braak and Braak is based on thesequential accumulation of neurofibrillary pathology in the cerebralcortex, Unlike the currently used diagnostic criteria for Alzheimer'sdisease (AD) it does not take into consideration the age of thepatients and whether they were demented or not for the establishmentof the pathological stage of the disease, To examine theinterobserver reliability of the method we performed an inter- andintra-rater study using the Braak staging method in 41 brains. Theagreement between the examiners and between the diagnoses of the sameexaminer at different times was almost perfect, the kappa statisticsreaching values above 0.90, These findings indicate that the staging,relying on the differential distribution of neuritic pathology in thebrain in AD, is a reliable and reproducible method for thedescription of AD-related pathology, This makes it suitable for brain-banking and research purposes.
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| Emner |
