The pathogenesis of Alzheimer disease: An alternative to the amyloidhypothesis
R.D. Terry
Bok Engelsk 1996
| Utgitt | 1996
|
|---|---|
| Omfang | Side 1023- 1025
|
| Opplysninger | This paper attempts to put together in the form of a flow sheet (Fig.1) the several known alterations, both chemical and structural, ofbrain tissue in Alzheimer disease, which ultimately result indementia. While most investigators in the field believe strongly thatamyloid deposition is at the core of the disease, this writer findsthat a more coherent, and thus more satisfying, schema can be basedon the centrality of cytoskeletal abnormality. Not only do all fouridentified genes interact one way or another with the cytoskeleton,but abnormality of the latter leads to alterations of the Golgiapparatus with effects on protein processing, and on axoplasmic flowsuch that one can expect loss of synapses and subsequent loss ofneurons with consequent disconnection and loss of neurotransmitters.Dementia is the result.
|
| Emner |
