A case-control study of smoking and Alzheimer's disease
E. Salib
Bok Engelsk 1997
| Utgitt | 1997
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| Omfang | 5 s.
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| Opplysninger | Objectives. To study the association between Alzheimer's disease and smoking history.Design. An unmatched case-control study.Setting. Psychogeriatric unit serving an elderly population of Warrington. Period. 2 years 1991-1993.Subjects. 198 cases of Alzheimer's disease (ADRDA-NINCDS diagnostic criteria) were compared to two selected control groups (164 other dementias and 176 non-dementing group) with respect to their smokinghistory.Main outcome measure. Relative risk (odds ratio) of Alzheimer's disease.Results. The odds ratio for Alzheimer's disease in patients who smoked was 0.68 (95% CI 0.47-0.98). The negative association was statistically significant only in male patients, OR 0.45 95% CI (0.23-0.87), p<0.05. The inverse association was also only significant in patients with family history of dementia, OR 0.34 95% CI (0.12-0.92),p<0.05.Conclusion. The study supports previous findings of an inverse relationship between smoking and Alzheimer's disease. This, however,does not suggest that smoking is used as a preventive measure for Alzheimer's disease.
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