Gangliosides and sulfatide in cerebrospinal fluid in leukoaraiosis
S. TarvonenSchroder
Bok Engelsk 1997
| Utgitt | 1997
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|---|---|
| Omfang | Side 174- 179
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| Opplysninger | The aim of the study was to evaluate gangliosides and sulfatide incerebrospinal fluid (CSF) as markers for neuronal degeneration,gliosis, and demyelination in leukoaraiosis (LA). Lumbar CSF sampleswere taken from 37 elderly subjects with LA on computed tomography(CT). Patients with other pathology than LA or infarction on CT wereexcluded. In addition, CSF samples were colleted from 16 elderlyreference subjects without any neurological disease. GangliosidesGM1, GD1a, GD1b, GT1b, GD3, and sulfatide were determined. Theconcentration of the individual gangliosides and sulfatide showed nocorrelation with age. Gangliosides GD1b, GT1b, and GD3 were elevatedin patients with mild LA compared to controls and patients withmoderate or severe LA. GD1a was elevated in patients with mild LAcompared to those with moderate LA. The concentration of sulfatidedid not differ between the groups. When the patients were grouped inaccordance to whether they had had cerebral infarction or not,differences between the groups were not found in the concentrationsof any gangliosides and sulfatide. In conclusion, the analysis of CSFmarkers suggests that neuronal degeneration and gliosis predominatein the early stage of LA.
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| Emner |
