Meta-analysis of post-mortem studies of Alzheimer's disease-like neuropathology in schizophrenia
Ross J. Baldessarini
Bok Engelsk 1997
| Utgitt | 1997
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|---|---|
| Omfang | 3 s.
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| Utgave | Kopi
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| Opplysninger | Conclusions: Suggestions that cerebral plaques and neurofibrillary tangles are more common in schizophrenia in associatin with neuroleptic treatment were not supported.. - Method: Neuropathological studies indicating the presence or absence of Alzheimer's disease - like neuropathology in the post-mortem brains of patients with schizophrenia, normal comparison subjects, and comparison subjects who had affective disorder were evaluated with Mantel-Haenszel chi-square and odds ratio analysis.. - OBJECTIVE: To evaluate the hypothesis that patients with schizophrenia who have been treated with neuroleptics have a high rate of Alzheimer's disease-like neuropathology.. - Results: Ten studies with relevant data were reviewed; none of eight with comparisons indicated that Alzheimer's disease-like neuropathology was more likely to be found in the brains of patients with schizophrenia than in brains of comparison subjects.
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| Emner |
